Price range: $268.00 through $328.00
Background:
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | BD-2 |
| Reactivity | Human |
| Applications | IHC, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA(peptide)1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Beta-defensin 4A AA range: 1-50 |
| Specificity | This antibody detects endogenous levels of human Beta-defensin 4A |
| Gene Name | DEFB4A DEFB102 DEFB2 DEFB4; DEFB4B |
| Protein Name | Beta-defensin 4A |
| Other Name | DEFB4A; / DEFB102; / DEFB2; / DEFB4; / DEFB4B; / Beta-defensin 4A; / Beta-defensin 2; / BD-2; / hBD-2; / Defensin; / beta 2; / Skin-antimicrobial peptide 1; / SAP1 |
| Species | Human |
| Gene ID | 100289462 |
| Uniprot | O15263 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed in the skin and respiratory tract. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Staphylococcus aureus infection |
| Function | Function:Has antibacterial activity .,induction:By inflammation.,similarity:Belongs to the beta-defensin family. LAP/TAP subfamily.,tissue specificity:Expressed in the skin and respiratory tract., |
