BMP-3 Polyclonal Antibody
Ucallm_WP11285-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],
Specifications
| Size | 50μL/100μL |
| Target | BMP-3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BMP-3. AA range:257-306 |
| Specificity | BMP-3 Polyclonal Antibody detects endogenous levels of BMP-3 protein. |
| Gene Name | BMP3 |
| Protein Name | Bone morphogenetic protein 3 |
| Other Name | BMP3; / BMP3A; / Bone morphogenetic protein 3; / BMP-3; / Bone morphogenetic protein 3A; / BMP-3A; / Osteogenin |
| Species | Human |
| Gene ID | 651 |
| Uniprot | P12645, |
| Species.1 | Mouse |
| Gene ID.1 | 110075 |
| Uniprot.1 | Q8BHE5, |
| Species.2 | Rat |
| Gene ID.2 | 25667 |
| Uniprot.2 | P49002 |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed in adult and fetal cartilage. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | Function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage., |
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