Name: BNC1 Polyclonal Antibody
SKU: WP0533
Price: 268 USD
Availability: InStock

BNC1 Polyclonal Antibody

Ucallm_WP0533-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP0533-100

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Product details

Background:

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014],

Specifications

Size	50μL/100μL
Target	BNC1
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	109kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 10-90
Specificity	BNC1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	BNC1 BNC
Protein Name	Zinc finger protein basonuclin-1
Other Name
Species	Human
Gene ID	646
Uniprot	Q01954,
Species.1	Mouse
Gene ID.1
Uniprot.1	O35914
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Cytoplasm . Nucleus, nucleoplasm . Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. .
Tissue Expression	In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312). Expressed in the ovary, notably in oocytes (PubMed:30010909).
Signaling_pathway
Research Areas
Function	Function:Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.,PTM:Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.,similarity:Contains 6 C2H2-type zinc fingers.,subcellular location:Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.,tissue specificity:Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart.,