SKU: WP0560 Categories: ,

BRSK2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0560-100
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Product details

Background:

catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins., sequence caution:Translated as Gly., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain.,

Specifications

Size50μL/100μL
TargetBRSK2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)80kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 320-400
SpecificityBRSK2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameBRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12
Protein NameSerine/threonine-protein kinase BRSK2
Other NameSerine/threonine-protein kinase BRSK2; / Brain-selective kinase 2; / Brain-specific serine/threonine-protein kinase 2; / BR serine/threonine-protein kinase 2; / Serine/threonine-protein kinase 29; / Serine/threonine-protein kinase SAD-A
SpeciesHuman
Gene ID9024
UniprotQ8IWQ3,
Species.1Mouse
Gene ID.175770
Uniprot.1Q69Z98,
Species.2Rat
Gene ID.2
Uniprot.2D3ZML2
Cellular LocalizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.
Tissue ExpressionDetected in pancreas islets (at protein level).
Signaling_pathway
Research Areas
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins.,sequence Caution:Translated as Gly.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,
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