BST-1 Polyclonal Antibody
Ucallm_WP11319-50
Price range: $268.00 through $328.00
Product details
Background:
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | BST-1 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120 |
| Specificity | BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein. |
| Gene Name | BST1 |
| Protein Name | ADP-ribosyl cyclase 2 |
| Other Name | BST1; / ADP-ribosyl cyclase 2; / Bone marrow stromal antigen 1; / BST-1; / Cyclic ADP-ribose hydrolase 2; / cADPr hydrolase 2; / CD antigen CD157 |
| Species | Human |
| Gene ID | 683 |
| Uniprot | Q10588, |
| Species.1 | Mouse |
| Gene ID.1 | 12182 |
| Uniprot.1 | Q64277, |
| Species.2 | Rat |
| Gene ID.2 | 81506 |
| Uniprot.2 | Q63072 |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Salivary secretion; / >>Pancreatic secretion |
| Function | Catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,Disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,Function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed., |
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