BTR1 Polyclonal Antibody
Ucallm_WP11324-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
Specifications
| Size | 50μL/100μL |
| Target | BTR1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC4A11. AA range:291-340 |
| Specificity | BTR1 Polyclonal Antibody detects endogenous levels of BTR1 protein. |
| Gene Name | SLC4A11 |
| Protein Name | Sodium bicarbonate transporter-like protein 11 |
| Other Name | SLC4A11; / BTR1; / Sodium bicarbonate transporter-like protein 11; / Bicarbonate transporter-related protein 1; / Sodium borate cotransporter 1; / NaBC1; / Solute carrier family 4 member 11 |
| Species | Human |
| Gene ID | 83959 |
| Uniprot | Q8NBS3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | A2AJN7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Basolateral cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.; [Isoform 3]: Expressed in corneal endothelium (at protein level).; [Isoform 5]: The predominant isoform in corneal endothelium (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]; also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive.,Disease:Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700]; also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.,Function:Transporter involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.,PTM:Glycosylated.,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,tissue specificity:Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes., |
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