C/EBP α Polyclonal Antibody
Ucallm_WP11330-50
Price range: $268.00 through $328.00
Product details
Background:
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],
Specifications
| Size | 50μL/100μL |
| Target | C/EBP α |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C/EBP-alpha. AA range:6-55 |
| Specificity | C/EBP α Polyclonal Antibody detects endogenous levels of C/EBP α protein. |
| Gene Name | CEBPA |
| Protein Name | CCAAT/enhancer-binding protein alpha |
| Other Name | CEBPA; / CCAAT/enhancer-binding protein alpha; / C/EBP alpha |
| Species | Human |
| Gene ID | 1050 |
| Uniprot | P49715, |
| Species.1 | Mouse |
| Gene ID.1 | 12606 |
| Uniprot.1 | P53566, |
| Species.2 | Rat |
| Gene ID.2 | 24252 |
| Uniprot.2 | P05554 |
| Cellular Localization | Nucleus .; [Isoform 4]: Nucleus, nucleolus . |
| Tissue Expression | Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia |
| Research Areas | >>Non-alcoholic fatty liver disease; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia |
| Function | Function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X., |
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