C/EBP ε Polyclonal Antibody
Ucallm_WP11334-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | C/EBP ε |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C/EBP-epsilon. AA range:40-89 |
| Specificity | C/EBP ε Polyclonal Antibody detects endogenous levels of C/EBP ε protein. |
| Gene Name | CEBPE |
| Protein Name | CCAAT/enhancer-binding protein epsilon |
| Other Name | CEBPE; / CCAAT/enhancer-binding protein epsilon; / C/EBP epsilon |
| Species | Human |
| Gene ID | 1053 |
| Uniprot | Q15744, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6PZD9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia |
| Research Areas | >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia |
| Function | Function:C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,online information:CEBPE mutation db,PTM:Phosphorylated.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.,tissue specificity:Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines., |
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