c-Fgr Polyclonal Antibody
Ucallm_WP11599-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | c-Fgr |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human N-ternal FGR. AA range:61-110 |
| Specificity | c-Fgr Polyclonal Antibody detects endogenous levels of c-Fgr protein. |
| Gene Name | FGR SRC2 |
| Protein Name | Tyrosine-protein kinase Fgr |
| Other Name | FGR; / SRC2; / Tyrosine-protein kinase Fgr; / Gardner-Rasheed feline sarcoma viral; / v-fgr; / oncogene homolog; / Proto-oncogene c-Fgr; / p55-Fgr; / p58-Fgr; / p58c-Fgr |
| Species | Human |
| Gene ID | 2268 |
| Uniprot | P09769, |
| Species.1 | Mouse |
| Gene ID.1 | 14191 |
| Uniprot.1 | P14234, |
| Species.2 | Rat |
| Gene ID.2 | 79113 |
| Uniprot.2 | Q6P6U0 |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side . Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. . |
| Tissue Expression | Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway |
| Research Areas | >>Chemokine signaling pathway |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Binds PTPNS1., |
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