Product details
Background:
- Please choose product options by visiting C1orf26 rabbit pAb.
- Please choose product options by visiting C1orf113 rabbit pAb.
C1orf51 rabbit pAb
Ucallm_WP7660-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CIART |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 42kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C1orf51 |
| Specificity | This antibody detects endogenous levels of C1orf51 at Human, Mouse |
| Gene Name | C1orf51 |
| Protein Name | Uncharacterized protein C1orf51 |
| Other Name | |
| Species | Human |
| Gene ID | 148523 |
| Uniprot | Q8N365, |
| Species.1 | Mouse |
| Gene ID.1 | 229599 |
| Uniprot.1 | Q3TQ03 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Nucleus, PML body . Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). |
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