C32 Polyclonal Antibody
Ucallm_WP15711-50
Price range: $268.00 through $328.00
Product details
Background:
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011],
Specifications
| Size | 50μL/100μL |
| Target | C32 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Chemokine-like factor at AA range: 103-152 |
| Specificity | C32 Polyclonal Antibody detects endogenous levels of C32 protein. |
| Gene Name | CKLF |
| Protein Name | Chemokine-like factor |
| Other Name | CKLF; / CKLF1; / HSPC224; / Chemokine-like factor; / C32 |
| Species | Human |
| Gene ID | 51192 |
| Uniprot | Q9UBR5, |
| Species.1 | Mouse |
| Gene ID.1 | 75458 |
| Uniprot.1 | Q9DAS1, |
| Species.2 | Rat |
| Gene ID.2 | 245978 |
| Uniprot.2 | Q9JK79 |
| Cellular Localization | [Isoform 1]: Secreted .; [Isoform 2]: Membrane; Multi-pass membrane protein .; [Isoform 4]: Membrane; Multi-pass membrane protein . |
| Tissue Expression | Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Isoform CKLF1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes.,Function:May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.,similarity:Belongs to the chemokine-like factor family.,similarity:Contains 1 MARVEL domain.,tissue specificity:All 4 isoforms have highest expression levels in adult spleen, lungs, testis, ovary, peripheral blood leucocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate, and fetal spleen and liver., |
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