CA IX [PTR2373] mouse mAb
Ucallm_WM1628-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CA IX |
| Reactivity | Human |
| Applications | IHC, ELISA |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR2373 |
| Immunogen | Recombinant protein |
| Specificity | This antibody detects endogenous levels of CA IX protein. |
| Gene Name | CA9 |
| Protein Name | Carbonic anhydrase 9 |
| Other Name | G250; / MN; / Carbonic anhydrase 9; / Carbonate dehydratase IX; / Carbonic anhydrase IX; / CA-IX; / CAIX; / Membrane antigen MN; / P54/58N; / Renal cell carcinoma-associated antigen G250; / RCC-associated antigen G250; / pMW1 |
| Species | Human |
| Gene ID | 768 |
| Uniprot | Q16790, |
| Species.1 | Mouse |
| Gene ID.1 | 230099 |
| Uniprot.1 | Q8VHB5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. |
| Signaling_pathway | |
| Research Areas | >>Nitrogen metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,Function:Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.,induction:By hypoxia.,PTM:Asn-346 bears high-mannose type glycan structures.,similarity:Belongs to the alpha-carbonic anhydrase family.,subcellular location:Found on the surface microvilli and in the nucleus, particularly in nucleolus.,subunit:Forms oligomers linked by disulfide bonds.,tissue specificity:Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa., |
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