Price range: $268.00 through $328.00
Background:
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | CABP4 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CABP4 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CABP4 |
| Protein Name | Calcium-binding protein 4 (CaBP4) |
| Other Name | |
| Species | Human |
| Gene ID | 57010 |
| Uniprot | P57796, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8VHC5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cell junction, synapse, presynapse . Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. . |
| Tissue Expression | Expressed in retina and in the inner hair cells (IHC) of the cochlea. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.,Function:May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages.,similarity:Contains 4 EF-hand domains.,subcellular location:Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.,subunit:Interacts with CACNA1F., |
