CACNG2 Polyclonal Antibody
Ucallm_WP5901-50
Price range: $268.00 through $328.00
Product details
Background:
calcium voltage-gated channel auxiliary subunit gamma 2(CACNG2) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010],
Specifications
| Size | 50μL/100μL |
| Target | CACNG2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; IHC 1:200-500; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of CACNG2 AA range: 58-108 |
| Specificity | The antibody detects endogenous CACNG2 protein. |
| Gene Name | CACNG2 |
| Protein Name | Voltage-dependent calcium channel gamma-2 subunit |
| Other Name | Voltage-dependent calcium channel gamma-2 subunit; / Neuronal voltage-gated calcium channel gamma-2 subunit; / Transmembrane AMPAR regulatory protein gamma-2; / TARP gamma-2 |
| Species | Human |
| Gene ID | 10369 |
| Uniprot | Q9Y698, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O88602, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q71RJ2 |
| Cellular Localization | Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome . |
| Tissue Expression | Brain. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Oxytocin signaling pathway; / >>Hypertrophic cardiomyopathy; / >>Arrhythmogenic right ventricular cardiomyopathy; / >>Dilated cardiomyopathy |
| Function | Function:Thought to stabilize the calcium channel in an inactivated (closed) state.,PTM:Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.,tissue specificity:Brain., |
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