Cadherin-8 Polyclonal Antibody
Ucallm_WP11376-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Cadherin-8 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 90kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDH8. AA range:491-540 |
| Specificity | Cadherin-8 Polyclonal Antibody detects endogenous levels of Cadherin-8 protein. |
| Gene Name | CDH8 |
| Protein Name | Cadherin-8 |
| Other Name | CDH8; / Cadherin-8 |
| Species | Human |
| Gene ID | 1006 |
| Uniprot | P55286, |
| Species.1 | Mouse |
| Gene ID.1 | 12564 |
| Uniprot.1 | P97291, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O54800 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts., |
Please login to post questions
Related products
