Name: Calnexin Monoclonal Antibody
SKU: WM0070
Price: 268 USD
Availability: InStock

Calnexin Monoclonal Antibody

Ucallm_WM0070-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM0070-50

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Product details

Background:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Calnexin
Reactivity	Human
Applications	WB, IF, ELISA
MW(Calculated)	68kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	10E1
Immunogen	Synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.
Specificity	Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein.
Gene Name	CANX
Protein Name	Calnexin
Other Name	CANX; / Calnexin; / IP90; / Major histocompatibility complex class I antigen-binding protein p88; / p90
Species	Human
Gene ID	821
Uniprot	P27824,
Species.1	Mouse
Gene ID.1
Uniprot.1	P35564
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Single-pass type I membrane protein . Endoplasmic reticulum . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). .
Tissue Expression	B-cell lymphoma,Epithelium,Fibroblast,Keratinocyte,Kidney,Liver,Lymph,Placenta,Platelet,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Antigen processing and presentation;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas	>>Protein processing in endoplasmic reticulum; / >>Phagosome; / >>Antigen processing and presentation; / >>Thyroid hormone synthesis; / >>Human T-cell leukemia virus 1 infection
Function	Function:Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.,online information:Calnexin entry,similarity:Belongs to the calreticulin family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,