Price range: $268.00 through $328.00
Background:
function:Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., miscellaneous:This protein has four functional calcium-binding sites., similarity:Belongs to the calcineurin regulatory subunit family., similarity:Contains 4 EF-hand domains., subunit:Composed of a catalytic subunit (A) and a regulatory subunit (B)., tissue specificity:Testis specific.,
| Size | 50μL/100μL |
| Target | CANB2 |
| Reactivity | Human, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 18kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CANB2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | PPP3R2 CBLP PPP3RL |
| Protein Name | Calcineurin subunit B type 2 (Calcineurin B-like protein) (CBLP) (Calcineurin BII) (CNBII) (PPP3R1-like) (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform) |
| Other Name | |
| Species | Human |
| Gene ID | 5535 |
| Uniprot | Q96LZ3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q63811, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P28470 |
| Cellular Localization | Mitochondrion . Localizes in the mitochondria in a SPATA33-dependent manner. . |
| Tissue Expression | Testis-specific. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> VEGF signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>Oocyte meiosis; / >>Cellular senescence; / >>Wnt signaling pathway; / >>Axon guidance; / >>VEGF signaling pathway; / >>Osteoclast differentiation; / >>C-type lectin receptor signaling pathway; / >>Natural killer cell mediated cytotoxicity; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>B cell receptor signaling pathway; / >>Long-term potentiation; / >>Glutamatergic synapse; / >>Oxytocin signaling pathway; / >>Glucagon signaling pathway; / >>Renin secretion; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Amphetamine addiction; / >>Tuberculosis; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Human immunodeficiency virus 1 infection; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Lipid and atherosclerosis |
| Function | Function:Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.,miscellaneous:This protein has four functional calcium-binding sites.,similarity:Belongs to the calcineurin regulatory subunit family.,similarity:Contains 4 EF-hand domains.,subunit:Composed of a catalytic subunit (A) and a regulatory subunit (B).,tissue specificity:Testis specific., |
