Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],
| Size | 50μL/100μL |
| Target | CBR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 32kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CBR1. AA range:181-230 |
| Specificity | Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein. |
| Gene Name | CBR1 |
| Protein Name | Carbonyl reductase [NADPH] 1 |
| Other Name | CBR1; / CBR; / CRN; / Carbonyl reductase [NADPH] 1; / 15-hydroxyprostaglandin dehydrogenase [NADP; / +; / ]; / NADPH-dependent carbonyl reductase 1; / Prostaglandin 9-ketoreductase; / Prostaglandin-E; / 2; / 9-reductase |
| Species | Human |
| Gene ID | 873 |
| Uniprot | P16152, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P48758 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in kidney (at protein level). |
| Signaling_pathway | |
| Research Areas | >>Arachidonic acid metabolism; / >>Folate biosynthesis; / >>Metabolism of xenobiotics by cytochrome P450; / >>Metabolic pathways; / >>Chemical carcinogenesis - DNA adducts; / >>Chemical carcinogenesis - reactive oxygen species |
| Function | Catalytic activity:(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.,Catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.,Catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,Function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Monomer., |
