CATB (Cleaved-Asn126) rabbit pAb
Ucallm_WP0111-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides., function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis., similarity:Belongs to the peptidase C1 family., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
Specifications
| Size | 50μL/100μL |
| Target | Cathepsin B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 15kD,37kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CATB (Cleaved-Asn126) |
| Specificity | This antibody detects endogenous levels of Human CATB (Cleaved-Asn126, protein was cleaved amino acid sequence between 126-127 ) |
| Gene Name | CTSB CPSB |
| Protein Name | CATB (Cleaved-Asn126) |
| Other Name | CTSB; / CPSB; / Cathepsin B; / APP secretase; / APPS; / Cathepsin B1; / [Cleaved into: Cathepsin B light chain; / Cathepsin B heavy chain] |
| Species | Human |
| Gene ID | 1508 |
| Uniprot | P07858, |
| Species.1 | Mouse |
| Gene ID.1 | 13030 |
| Uniprot.1 | P10605, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P00787 |
| Cellular Localization | Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane; Peripheral membrane protein; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). . |
| Tissue Expression | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome;Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Cell growth and death >> Apoptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Antigen processing and presentation |
| Research Areas | >>Autophagy - animal; / >>Lysosome; / >>Apoptosis; / >>Antigen processing and presentation; / >>NOD-like receptor signaling pathway; / >>Renin secretion |
| Function | proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death, |
Please login to post questions
Related products
