SKU: WP0031 Categories: ,

Cathepsin H Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0031-100
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Product details

Background:

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],

Specifications

Size50μL/100μL
TargetCathepsin H
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; IF 1:50-200
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Cathepsin H . at AA range: 220-300
SpecificityCathepsin H Polyclonal Antibody detects endogenous levels of Cathepsin H protein.
Gene NameCTSH
Protein NamePro-cathepsin H
Other NameCTSH; / CPSB; / Pro-cathepsin H
SpeciesHuman
Gene ID1512
UniprotP09668,
Species.1Mouse
Gene ID.1
Uniprot.1P49935
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationLysosome.
Tissue ExpressionCartilage,Eye,Kidney,Liver,Lung,Salivary gland,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Lysosome;Cellular Processes >> Cell growth and death >> Apoptosis
Research Areas>>Lysosome; / >>Apoptosis
FunctionCatalytic activity:Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.,Function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.,
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