Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human CBLL1
Specificity
This antibody detects endogenous levels of CBLL1 at Human, Mouse
Gene Name
CBLL1 HAKAI RNF188
Protein Name
E3 ubiquitin-protein ligase Hakai (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (RING finger protein 188) (c-Cbl-like protein 1)
Other Name
Species
Human
Gene ID
79872
Uniprot
Q75N03,
Species.1
Mouse
Gene ID.1
104836
Uniprot.1
Q9JIY2
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. .
Tissue Expression
Signaling_pathway
Research Areas
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Its function in the WMM complex is unknown .