Product details
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CBS rabbit pAb
Ucallm_WP5959-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CBS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 61kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CBS |
| Specificity | This antibody detects endogenous levels of CBS at Human, Mouse,Rat |
| Gene Name | CBS |
| Protein Name | Cystathionine beta-synthase (Beta-thionase) (Serine sulfhydrase) |
| Other Name | |
| Species | Human |
| Gene ID | 875 |
| Uniprot | P35520, |
| Species.1 | Mouse |
| Gene ID.1 | 12411 |
| Uniprot.1 | Q91WT9, |
| Species.2 | Rat |
| Gene ID.2 | 24250 |
| Uniprot.2 | P32232 |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine . Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). |
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