Price range: $268.00 through $328.00
Background:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011],
| Size | 50μL/100μL |
| Target | CCDC8 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 59kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CCDC8 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CCDC8 |
| Protein Name | Coiled-coil domain-containing protein 8 |
| Other Name | |
| Species | Human |
| Gene ID | 83987 |
| Uniprot | Q9H0W5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | D3YZV8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P62521 |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . |
| Tissue Expression | Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., |
