Name: U-Blot® CCR7 Rabbit mAb
SKU: WR5056
Price: 268 USD
Availability: InStock

U-Blot® CCR7 Rabbit mAb

Ucallm_WR5056-50

Price range: $268.00 through $328.00

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SKU: WR5056-50

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Product details

Background:The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014],

Specifications

Size	50μL/100μL
Target	CCR7
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	43kD
MW(Observed)	43kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1290R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CCR7
Protein Name	C-C chemokine receptor type 7
Other Name	CCR7; / CMKBR7; / EBI1; / EVI1; / C-C chemokine receptor type 7; / C-C CKR-7; / CC-CKR-7; / CCR-7; / BLR2; / CDw197; / Epstein-Barr virus-induced G-protein coupled receptor 1; / EBI1; / EBV-induced G-protein coupled receptor 1; / MIP-3 beta receptor; / CD antigen CD19
Species	Human
Gene ID	1236
Uniprot	P32248,
Species.1	Mouse
Gene ID.1
Uniprot.1	P47774
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Expression	Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Signaling_pathway	Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway
Function	Function:Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.,induction:By EBV.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.,