CD10 Polyclonal Antibody
Ucallm_WP15398-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this
Specifications
| Size | 50μL/100μL |
| Target | CD10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MME. AA range:491-540 |
| Specificity | CD10 Polyclonal Antibody detects endogenous levels of CD10 protein. |
| Gene Name | MME EPN |
| Protein Name | Neprilysin |
| Other Name | MME; / EPN; / Neprilysin; / Atriopeptidase; / Common acute lymphocytic leukemia antigen; / CALLA; / Enkephalinase; / Neutral endopeptidase 24.11; / NEP; / Neutral endopeptidase; / Skin fibroblast elastase; / SFE; / CD10 |
| Species | Human |
| Gene ID | 4311 |
| Uniprot | P08473, |
| Species.1 | Mouse |
| Gene ID.1 | 17380 |
| Uniprot.1 | Q61391, |
| Species.2 | Rat |
| Gene ID.2 | 24590 |
| Uniprot.2 | P07861 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. |
| Tissue Expression | Adrenal cortex,Brain,Kidney,Placenta, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Endocrine system >> Renin-angiotensin system;Human Diseases >> Neurodegenerative disease >> Alzheimer disease |
| Research Areas | >>Renin-angiotensin system; / >>Hematopoietic cell lineage; / >>Protein digestion and absorption; / >>Alzheimer disease |
| Function | Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,Disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,Function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family., |
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