SKU: WP15332 Categories: ,

CD116 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15332-100
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Product details

Background:

The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD116
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)44kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CSF2RA. AA range:121-170
SpecificityCD116 Polyclonal Antibody detects endogenous levels of CD116 protein.
Gene NameCSF2RA
Protein NameGranulocyte-macrophage colony-stimulating factor receptor subunit alpha
Other NameCSF2RA; / CSF2R; / CSF2RY; / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; / GM-CSF-R-alpha; / GMCSFR-alpha; / GMR-alpha; / CDw116; / CD116
SpeciesHuman
Gene ID1438
UniprotP15509,
Species.1Mouse
Gene ID.1
Uniprot.1Q00941
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 6]: Secreted .
Tissue ExpressionBlood,Placenta,Synovial membrane tissue,Uterus,
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage; / >>Pathways in cancer
FunctionDomain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
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