CD137 Polyclonal Antibody
Ucallm_WP11472-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD137 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 27kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFRSF9. AA range:101-150 |
| Specificity | CD137 Polyclonal Antibody detects endogenous levels of CD137 protein. |
| Gene Name | TNFRSF9 |
| Protein Name | Tumor necrosis factor receptor superfamily member 9 |
| Other Name | TNFRSF9; / CD137; / ILA; / Tumor necrosis factor receptor superfamily member 9; / 4-1BB ligand receptor; / CDw137; / T-cell antigen 4-1BB homolog; / T-cell antigen ILA; / CD antigen CD137 |
| Species | Human |
| Gene ID | 3604 |
| Uniprot | Q07011, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P20334 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed on the surface of activated T-cells. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | Function:Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.,tissue specificity:Expressed on the surface of activated T-cells., |
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