Price range: $268.00 through $328.00
Background:
The protein encoded byThis gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
| Size | 50μL/100μL |
| Target | CD40 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | Please check the information on the tube |
| Clonality | Monoclonal |
| Clone Number | RMMR1386 |
| Immunogen | Purified recombinant Human CD14 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD14 protein. |
| Gene Name | CD14 |
| Protein Name | Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form] |
| Other Name | Monocyte differentiation antigen CD14; / Myeloid cell-specific leucine-rich glycoprotein; / CD antigen CD14; / [Cleaved into: Monocyte differentiation antigen CD14; / urinary form; / Monocyte differentiation antigen CD14; / membrane-bound form] |
| Species | Human |
| Gene ID | 958 |
| Uniprot | P08571, |
| Species.1 | Mouse |
| Gene ID.1 | 21939 |
| Uniprot.1 | P27512 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Secreted forms may arise by cleavage of the GPI anchor. . |
| Tissue Expression | B-cells and in primary carcinomas. |
| Signaling_pathway | Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Immune disease >> Asthma;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>NF-kappa B signaling pathway; / >>Cell adhesion molecules; / >>Toll-like receptor signaling pathway; / >>Intestinal immune network for IgA production; / >>Malaria; / >>Toxoplasmosis; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Transcriptional misregulation in cancer; / >>Asthma; / >>Autoimmune thyroid disease; / >>Systemic lupus erythematosus; / >>Allograft rejection; / >>Primary immunodeficiency; / >>Viral myocarditis; / >>Lipid and atherosclerosis |
| Function | Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages., |
