CD180 Polyclonal Antibody
Ucallm_WP15624-50
Price range: $268.00 through $328.00
Product details
Background:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD180 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from CD180 antigen at AA range: 221-270 |
| Specificity | CD180 Polyclonal Antibody detects endogenous levels of CD180 protein. |
| Gene Name | CD180 |
| Protein Name | CD180 antigen |
| Other Name | CD180; / LY64; / RP105; / CD180 antigen; / Lymphocyte antigen 64; / Radioprotective 105 kDa protein; / CD180 |
| Species | Human |
| Gene ID | 4064 |
| Uniprot | Q99467, |
| Species.1 | Mouse |
| Gene ID.1 | 17079 |
| Uniprot.1 | Q62192 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.,Function:May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 17 LRR (leucine-rich) repeats.,subunit:Binds to MD-1.,tissue specificity:Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells., |
Please login to post questions
Related products
