Price range: $268.00 through $328.00
Background:
CD2 is a 50-55 kDa transmembrane glycoprotein present on all peripheral T cells, lymphocytes and NK cells. The main function is to regulate activated T cells and mediate thymocyte thymic epithelial adhesion. CD2 expression may be abnormally absent in T-cell lymphoma, which is helpful to distinguish reactive T-cell proliferation. It is mainly used for the diagnosis and differentiation of tumors derived from T cells and NK cells.
| Size | 50μL/100μL |
| Target | CD2 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 39kD |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM529 |
| Immunogen | Synthesized peptide derived from human CD2 AA range: 1-100 |
| Specificity | The antibody can specifically recognize human CD2 protein. |
| Gene Name | CD2 SRBC |
| Protein Name | CD 2; CD2; CD2 antigen (p50), sheep red blood cell receptor; CD2 antigen; CD2 molecule; CD2_HUMAN; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; LFA2; LFA3 receptor; Ly-37; Lymphocyte function antigen 2; lymphocyte-function antigen-2; OTTHUMP00000024366; Rosette receptor; Sheep erythrocyte receptor; SRBC; T cell surface antigen CD2; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T-lymphocyte surface CD2 antigen; T11 |
| Other Name | CD 2; / CD2; / CD2 antigen; / p50; / , sheep red blood cell receptor; / CD2 antigen; / CD2 molecule; / CD2_HUMAN; / Erythrocyte receptor; / FLJ46032; / LFA-2; / LFA-3 receptor; / LFA2; / LFA3 receptor; / Ly-37; / Lymphocyte function antigen 2; / lymphocyte-function antigen-2; / OTTHUMP00000024366; / Rosette receptor; / Sheep erythrocyte receptor; / SRBC; / T cell surface antigen CD2; / T-cell surface antigen CD2; / T-cell surface antigen T11/Leu-5; / T-lymphocyte surface CD2 antigen; / T11 |
| Species | Human |
| Gene ID | 914 |
| Uniprot | P06729 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Tonsil |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Hematopoietic cell lineage |
| Function | Function:CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.,online information:CD2 entry,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with CD2AP (By similarity). Interacts with PSTPIP1., |
