Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016],
| Size | 50μL/100μL |
| Target | CD2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 39kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 3F3 |
| Immunogen | Synthetic Peptide of CD2 |
| Specificity | The antibody detects endogenous CD2 proteins. |
| Gene Name | CD2 |
| Protein Name | T-cell surface antigen CD2 |
| Other Name | CD2; / SRBC; / T-cell surface antigen CD2; / Erythrocyte receptor; / LFA-2; / LFA-3 receptor; / Rosette receptor; / T-cell surface antigen T11/Leu-5; / CD2 |
| Species | Human |
| Gene ID | 914 |
| Uniprot | P06729, |
| Species.1 | Mouse |
| Gene ID.1 | 12481 |
| Uniprot.1 | P08920, |
| Species.2 | Rat |
| Gene ID.2 | 497761 |
| Uniprot.2 | P08921 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Expressed in natural killer cells (at protein level). |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Hematopoietic cell lineage |
| Function | Function:CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.,online information:CD2 entry,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with CD2AP (By similarity). Interacts with PSTPIP1., |
