CD201 Polyclonal Antibody
Ucallm_WP15353-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | CD201 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 26kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Endothelial protein C receptor at AA range: 141-190 |
| Specificity | CD201 Polyclonal Antibody detects endogenous levels of CD201 protein. |
| Gene Name | PROCR |
| Protein Name | Endothelial protein C receptor |
| Other Name | PROCR; / EPCR; / Endothelial protein C receptor; / Activated protein C receptor; / APC receptor; / Endothelial cell protein C receptor; / CD201 |
| Species | Human |
| Gene ID | 10544 |
| Uniprot | Q9UNN8, |
| Species.1 | Mouse |
| Gene ID.1 | 19124 |
| Uniprot.1 | Q64695, |
| Species.2 | Rat |
| Gene ID.2 | 362248 |
| Uniprot.2 | Q4V8I1 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades |
| Function | Function:Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.,PTM:A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.,PTM:N-glycosylated.,tissue specificity:Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney., |
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