SKU: WP15634 Categories: ,

CD206 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15634-100
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Product details

Background:

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],

Specifications

Size50μL/100μL
TargetCD206
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)170kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390
SpecificityCD206 Polyclonal Antibody detects endogenous levels of CD206 protein.
Gene NameMRC1
Protein NameMacrophage mannose receptor 1
Other NameMRC1; / CLEC13D; / CLEC13DL; / MRC1L1; / Macrophage mannose receptor 1; / MMR; / C-type lectin domain family 13 member D; / C-type lectin domain family 13 member D-like; / Macrophage mannose receptor 1-like protein 1; / CD206
SpeciesHuman
Gene ID4360
UniprotP22897,
Species.1Mouse
Gene ID.117533
Uniprot.1Q61830
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndosome membrane; Single-pass type I membrane protein . Cell membrane; Single-pass type I membrane protein .
Tissue ExpressionMilk,Placenta,Testis,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome
Research Areas>>Phagosome; / >>Tuberculosis
FunctionFunction:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
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