CD236 Polyclonal Antibody
Ucallm_WP15879-50
Price range: $268.00 through $328.00
Product details
Background:
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012],
Specifications
| Size | 50μL/100μL |
| Target | CD236 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 11-60 |
| Specificity | The antibody detects endogenous CD236 |
| Gene Name | GYPC GLPC GPC |
| Protein Name | Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) |
| Other Name | Glycophorin-C; / Glycoconnectin; / Glycophorin-D; / GPD; / Glycoprotein beta; / PAS-2'; / Sialoglycoprotein D; / CD antigen CD236 |
| Species | Human |
| Gene ID | 2995 |
| Uniprot | P04921, |
| Species.1 | Mouse |
| Gene ID.1 | 71683 |
| Uniprot.1 | Q78HU7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type III membrane protein. Linked to the membrane via band 4.1. |
| Tissue Expression | Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | >>Malaria |
| Function | Function:This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin C plays an important role in regulating the stability of red cells.,online information:Blood group antigen gene mutation database,online information:Glycophorin C entry,polymorphism:GYPC is responsible for the Gerbich blood group system.,subcellular location:Linked to the membrane via Band 4.1.,tissue specificity:Glycophorin C is expressed in erythrocytes. Glycophorin D is ubiquitous., |
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