Name: CD24 Polyclonal Antibody
SKU: WP11487
Price: 268 USD
Availability: InStock

CD24 Polyclonal Antibody

Ucallm_WP11487-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP11487-100

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Product details

Background:

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

Specifications

Size	50μL/100μL
Target	CD24
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	35,45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human CD24. AA range:14-63
Specificity	CD24 Polyclonal Antibody detects endogenous levels of CD24 protein.
Gene Name	CD24
Protein Name	Signal transducer CD24
Other Name	CD24; / CD24A; / Signal transducer CD24; / Small cell lung carcinoma cluster 4 antigen; / CD antigen CD24
Species	Human
Gene ID	100133941
Uniprot	P25063,
Species.1	Mouse
Gene ID.1	12484
Uniprot.1	P24807,
Species.2	Rat
Gene ID.2	25145
Uniprot.2	Q07490
Cellular Localization	Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Expression	B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas	>>Hematopoietic cell lineage
Function	Disease:Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.,Function:Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.,induction:Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.,PTM:Extensively O-glycosylated.,similarity:Belongs to the CD24 family.,subunit:Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.,tissue specificity:B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.,