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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CD25 Monoclonal Antibody [Q22]
SKU: WM1037 Categories: ,

CD25 Monoclonal Antibody [Q22]

Ucallm_WM1037-50

Price range: $268.00 through $328.00

SKU: WM1037-50
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Product details

Background:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009],

Specifications

Size50μL/100μL
TargetCD25
ReactivityHuman
ApplicationsIHC, IF
MW(Calculated)31kD
MW(Observed)
Host SpeciesMouse
IsotypeIgM,kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberQ22
ImmunogenSynthetic Peptide of CD25
SpecificityThe antibody detects endogenous human CD25 protein.
Gene NameIL2RA
Protein NameInterleukin-2 receptor subunit alpha
Other NameIL2RA; / Interleukin-2 receptor subunit alpha; / IL-2 receptor subunit alpha; / IL-2-RA; / IL-2R subunit alpha; / IL2-RA; / TAC antigen; / p55; / CD25
SpeciesHuman
Gene ID3559
UniprotP01589,
Species.1Mouse
Gene ID.116184
Uniprot.1P01590,
Species.2Rat
Gene ID.225704
Uniprot.2P26897
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionThymus,
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Endocytosis; / >>PI3K-Akt signaling pathway; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer
FunctionDisease:Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].,Function:Receptor for interleukin-2.,online information:IL2RA mutation db,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.,
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Immunohistochemical analysis of paraffin-embedded Rat liver tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).
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