CD25 Monoclonal Antibody [Q22]
Ucallm_WM1037-50
Price range: $268.00 through $328.00
Product details
Background:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009],
Specifications
| Size | 50μL/100μL |
| Target | CD25 |
| Reactivity | Human |
| Applications | IHC, IF |
| MW(Calculated) | 31kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgM,kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | Q22 |
| Immunogen | Synthetic Peptide of CD25 |
| Specificity | The antibody detects endogenous human CD25 protein. |
| Gene Name | IL2RA |
| Protein Name | Interleukin-2 receptor subunit alpha |
| Other Name | IL2RA; / Interleukin-2 receptor subunit alpha; / IL-2 receptor subunit alpha; / IL-2-RA; / IL-2R subunit alpha; / IL2-RA; / TAC antigen; / p55; / CD25 |
| Species | Human |
| Gene ID | 3559 |
| Uniprot | P01589, |
| Species.1 | Mouse |
| Gene ID.1 | 16184 |
| Uniprot.1 | P01590, |
| Species.2 | Rat |
| Gene ID.2 | 25704 |
| Uniprot.2 | P26897 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Thymus, |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Endocytosis; / >>PI3K-Akt signaling pathway; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer |
| Function | Disease:Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].,Function:Receptor for interleukin-2.,online information:IL2RA mutation db,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain., |
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