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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CD269 Polyclonal Antibody
SKU: WP15679 Categories: ,

CD269 Polyclonal Antibody

Ucallm_WP15679-50

Price range: $268.00 through $328.00

SKU: WP15679-100
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Product details

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD269/BCMA
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)20kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human CD269.
SpecificityCD269 Polyclonal Antibody detects endogenous levels of CD269 protein.
Gene NameTNFRSF17 BCM BCMA
Protein NameTumor necrosis factor receptor superfamily member 17
Other NameTNFRSF17; / BCM; / BCMA; / Tumor necrosis factor receptor superfamily member 17; / B-cell maturation protein; / CD269
SpeciesHuman
Gene ID608
UniprotQ02223,
Species.1Mouse
Gene ID.1
Uniprot.1O88472
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
Tissue ExpressionExpressed in mature B-cells, but not in T-cells or monocytes.
Signaling_pathwayOrganismal Systems >> Immune system >> Intestinal immune network for IgA production;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction; / >>Intestinal immune network for IgA production
FunctionDisease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4; 16)(q26; p13) with IL2.,Function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
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