Price range: $268.00 through $328.00
Background:
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011],
| Size | 50μL/100μL |
| Target | CD294 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PTGDR2. AA range:161-210 |
| Specificity | CD294 Polyclonal Antibody detects endogenous levels of CD294 protein. |
| Gene Name | PTGDR2 |
| Protein Name | Prostaglandin D2 receptor 2 |
| Other Name | PTGDR2; / CRTH2; / DL1R; / GPR44; / Prostaglandin D2 receptor 2; / Chemoattractant receptor-homologous molecule expressed on Th2 cells; / G-protein coupled receptor 44; / CD294 |
| Species | Human |
| Gene ID | 11251 |
| Uniprot | Q9Y5Y4, |
| Species.1 | Mouse |
| Gene ID.1 | 14764 |
| Uniprot.1 | Q9Z2J6, |
| Species.2 | Rat |
| Gene ID.2 | 309212 |
| Uniprot.2 | Q6XKD3 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Internalized receptors colocalized with RAB11A. . |
| Tissue Expression | Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family., |
