Name: CD3 [ABT295] mouse mAb
SKU: WM1320
Price: 268 USD
Availability: InStock

Product details

Background:
CD3 protein contains ε、γ、δ and ζ four subunits, including extracellular, transmembrane and intracellular domains. CD3 is a T cell marker, which is not expressed by B cells. CD3 complex mediates TCR antigen recognition, leading to T cell proliferation and cytokine release. It is mainly used for the diagnosis of T-cell lymphoma, with high specificity but low sensitivity. In order to improve the accuracy of diagnosis, it is usually combined with CD45RO in clinical application.

Specifications

Size	50μL/100μL
Target	CD3E
Reactivity	Human
Applications	IHC, WB, IF, ELISA
MW(Calculated)	23kD
MW(Observed)	23kD
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM295
Immunogen	Synthesized peptide derived from human CD3, CD3E AA range: 1-100
Specificity	The antibody can specifically recognize human CD3e protein, and shows no reaction with CD3d or CD3g. In western blotting of Jurkat cell lysate, the antibody can label a 23 kDa band corresponding to CD3e.
Gene Name	CD3E T3E
Protein Name	CD3, CD3E
Other Name	4930549J05Rik; / A430104F18Rik; / AW552088; / Cd247; / CD247 antigen; / CD247 antigen, zeta subunit; / CD247 molecule; / CD3; / CD3 antigen, delta subunit; / CD3 delta; / CD3 epsilon; / CD3 eta; / CD3 gamma; / CD3 molecule delta polypeptide; / CD3 molecule, epsilon polypeptide; / CD3 molecule, gamma polypeptide; / CD3 zeta; / CD3-DELTA; / CD3d; / CD3D antigen delta polypeptide; / CD3d antigen, delta polypeptide; / TiT3 complex; / CD3d molecule delta; / CD3d molecule delta CD3 TCR complex; / CD3d molecule, delta; / CD3-TCR complex; / CD3D_HUMAN; / CD3E; / CD3e antigen; / CD3E antigen epsilon polypeptide; / CD3e antigen, epsilon polypeptide; / TiT3 complex; / CD3e molecule epsilon; / CD3e molecule epsilon CD3 TCR complex; / CD3e molecule, epsilon; / CD3-TCR complex; / CD3epsilon; / CD3G; / CD3g antigen; / CD3G antigen gamma polypeptide; / CD3g antigen, gamma polypeptide; / TiT3 complex; / CD3g molecule gamma; / CD3g molecule gamma CD3 TCR complex; / CD3g molecule, gamma; / CD3-TCR complex; / CD3H; / CD3Q; / CD3Z; / CD3zeta; / Ctg3; / FLJ17620; / FLJ17664; / FLJ18683; / FLJ79544; / FLJ94613; / IMD19; / Leu-4; / MGC138597; / OKT3, delta chain; / OTTHUMP00000032544; / T cell receptor; / T cell receptor T3 delta chain; / T cell receptor T3 gamma chain; / T cell receptor T3 zeta chain; / T cell receptor zeta chain; / T cell surface antigen T3/Leu 4 epsilon chain; / T cell surface glycoprotein CD3; / T cell surface glycoprotein CD3 delta chain; / T cell surface glycoprotein CD3 epsilon chain; / T cell surface glycoprotein CD3 gamma chain; / T cell surface glycoprotein CD3 zeta chain; / T-cell antigen receptor complex, delta subunit of T3; / T-cell antigen receptor complex, epsilon subunit of T3; / T-cell antigen receptor complex, gamma subunit of T3; / T-cell antigen receptor complex, zeta subunit of CD3; / T-cell receptor T3 delta chain; / T-cell receptor T3 gamma chain; / T-cell surface antigen T3/Leu-4 epsilon chain; / T-cell surface glycoprotein CD3 delta chain; / T-cell surface glycoprotein CD3 epsilon chain; / T-cell surface glycoprotein CD3 gamma chain; / T3; / T3d; / T3e; / T3g; / T3z; / TCRE; / TCRk; / Tcrz; / TCRzeta
Species	Human
Gene ID	916
Uniprot	P07766
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membranous
Tissue Expression	Membranous
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency
Research Areas	>>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Chagas disease; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Primary immunodeficiency
Function	Function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,

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CD3 [ABT295] mouse mAb

Product details

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CD3 [ABT295] mouse mAb

Product details

Specifications

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