CD3 [ABT295] mouse mAb
Ucallm_WM1320-50
Price range: $268.00 through $328.00
Product details
Background:
CD3 protein contains ε、γ、δ and ζ four subunits, including extracellular, transmembrane and intracellular domains. CD3 is a T cell marker, which is not expressed by B cells. CD3 complex mediates TCR antigen recognition, leading to T cell proliferation and cytokine release. It is mainly used for the diagnosis of T-cell lymphoma, with high specificity but low sensitivity. In order to improve the accuracy of diagnosis, it is usually combined with CD45RO in clinical application.
Specifications
| Size | 50μL/100μL |
| Target | CD3E |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 23kD |
| MW(Observed) | 23kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM295 |
| Immunogen | Synthesized peptide derived from human CD3, CD3E AA range: 1-100 |
| Specificity | The antibody can specifically recognize human CD3e protein, and shows no reaction with CD3d or CD3g. In western blotting of Jurkat cell lysate, the antibody can label a 23 kDa band corresponding to CD3e. |
| Gene Name | CD3E T3E |
| Protein Name | CD3, CD3E |
| Other Name | 4930549J05Rik; / A430104F18Rik; / AW552088; / Cd247; / CD247 antigen; / CD247 antigen, zeta subunit; / CD247 molecule; / CD3; / CD3 antigen, delta subunit; / CD3 delta; / CD3 epsilon; / CD3 eta; / CD3 gamma; / CD3 molecule delta polypeptide; / CD3 molecule, epsilon polypeptide; / CD3 molecule, gamma polypeptide; / CD3 zeta; / CD3-DELTA; / CD3d; / CD3D antigen delta polypeptide; / CD3d antigen, delta polypeptide; / TiT3 complex; / CD3d molecule delta; / CD3d molecule delta CD3 TCR complex; / CD3d molecule, delta; / CD3-TCR complex; / CD3D_HUMAN; / CD3E; / CD3e antigen; / CD3E antigen epsilon polypeptide; / CD3e antigen, epsilon polypeptide; / TiT3 complex; / CD3e molecule epsilon; / CD3e molecule epsilon CD3 TCR complex; / CD3e molecule, epsilon; / CD3-TCR complex; / CD3epsilon; / CD3G; / CD3g antigen; / CD3G antigen gamma polypeptide; / CD3g antigen, gamma polypeptide; / TiT3 complex; / CD3g molecule gamma; / CD3g molecule gamma CD3 TCR complex; / CD3g molecule, gamma; / CD3-TCR complex; / CD3H; / CD3Q; / CD3Z; / CD3zeta; / Ctg3; / FLJ17620; / FLJ17664; / FLJ18683; / FLJ79544; / FLJ94613; / IMD19; / Leu-4; / MGC138597; / OKT3, delta chain; / OTTHUMP00000032544; / T cell receptor; / T cell receptor T3 delta chain; / T cell receptor T3 gamma chain; / T cell receptor T3 zeta chain; / T cell receptor zeta chain; / T cell surface antigen T3/Leu 4 epsilon chain; / T cell surface glycoprotein CD3; / T cell surface glycoprotein CD3 delta chain; / T cell surface glycoprotein CD3 epsilon chain; / T cell surface glycoprotein CD3 gamma chain; / T cell surface glycoprotein CD3 zeta chain; / T-cell antigen receptor complex, delta subunit of T3; / T-cell antigen receptor complex, epsilon subunit of T3; / T-cell antigen receptor complex, gamma subunit of T3; / T-cell antigen receptor complex, zeta subunit of CD3; / T-cell receptor T3 delta chain; / T-cell receptor T3 gamma chain; / T-cell surface antigen T3/Leu-4 epsilon chain; / T-cell surface glycoprotein CD3 delta chain; / T-cell surface glycoprotein CD3 epsilon chain; / T-cell surface glycoprotein CD3 gamma chain; / T3; / T3d; / T3e; / T3g; / T3z; / TCRE; / TCRk; / Tcrz; / TCRzeta |
| Species | Human |
| Gene ID | 916 |
| Uniprot | P07766 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous |
| Tissue Expression | Membranous |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency |
| Research Areas | >>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Chagas disease; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Primary immunodeficiency |
| Function | Function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta., |
Please login to post questions
Related products
