CD32-B/C Polyclonal Antibody
Ucallm_WP15318-50
Price range: $268.00 through $328.00
Product details
Background:
Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Specifications
| Size | 50μL/100μL |
| Target | CD32 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190 |
| Specificity | CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein. |
| Gene Name | FCGR2B/FCGR2C |
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c |
| Other Name | FCGR2B; / CD32; / FCG2; / IGFR2; / Low affinity immunoglobulin gamma Fc region receptor II-b; / IgG Fc receptor II-b; / CDw32; / Fc-gamma RII-b; / Fc-gamma-RIIb; / FcRII-b; / CD32; / FCGR2C; / CD32; / FCG2; / IGFR2; / Low affinity immunoglobulin gamma Fc region receptor II-c; / IgG Fc receptor II-c; / CDw32; / Fc-gamma RII-c; / Fc-gamma-RIIc; / FcRII-c; / CD32 |
| Species | Human |
| Gene ID | 2213 |
| Uniprot | P31994 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation |
| Research Areas | >>Phagosome; / >>Osteoclast differentiation; / >>B cell receptor signaling pathway; / >>Fc gamma R-mediated phagocytosis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Measles |
| Function | immune response, |
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