Price range: $268.00 through $328.00
Background:
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011],
| Size | 50μL/100μL |
| Target | CD320 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 31kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 100-180 |
| Specificity | CD320 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CD320 8D6A UNQ198/PRO224 |
| Protein Name | CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) |
| Other Name | |
| Species | Human |
| Gene ID | 51293 |
| Uniprot | Q9NPF0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z1P5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5HZW5 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631). Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.,similarity:Contains 2 LDL-receptor class A domains.,tissue specificity:Expressed abundantly on follicular dendritic cells (FDCs)., |
