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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CD57 Polyclonal Antibody
SKU: WP11510 Categories: ,

CD57 Polyclonal Antibody

Ucallm_WP11510-50

Price range: $268.00 through $328.00

SKU: WP11510-100
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Product details

Background:

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD57
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)38kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CD57. AA range:35-84
SpecificityCD57 Polyclonal Antibody detects endogenous levels of CD57 protein.
Gene NameB3GAT1
Protein NameGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Other NameB3GAT1; / GLCATP; / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; / Beta-1; / 3-glucuronyltransferase 1; / Glucuronosyltransferase P; / GlcAT-P; / UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; / GlcUAT-P
SpeciesHuman
Gene ID27087
UniprotQ9P2W7,
Species.1Mouse
Gene ID.1
Uniprot.1Q9CW73,
Species.2Rat
Gene ID.2117108
Uniprot.2O35789
Cellular Localization[Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .
Tissue ExpressionMainly expressed in the brain.
Signaling_pathway
Research Areas>>Mannose type O-glycan biosynthesis; / >>Metabolic pathways
FunctionCatalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,Function:Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 43 family.,subunit:Homodimer .,tissue specificity:Mainly expressed in the brain.,
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