CD66e Monoclonal Antibody
Ucallm_WM0102-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Specifications
| Size | 50μL/100μL |
| Target | CEA |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 77kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 2D4 |
| Immunogen | Purified recombinant fragment of human CD66e expressed in E. Coli. |
| Specificity | CD66e Monoclonal Antibody detects endogenous levels of CD66e protein. |
| Gene Name | CEACAM5 |
| Protein Name | Carcinoembryonic antigen-related cell adhesion molecule 5 |
| Other Name | CEACAM5; / CEA; / Carcinoembryonic antigen-related cell adhesion molecule 5; / Carcinoembryonic antigen; / CEA; / Meconium antigen 100; / CD antigen CD66e |
| Species | Human |
| Gene ID | 1048 |
| Uniprot | P06731, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3UKK2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . Apical cell membrane . Cell surface . Localized to the apical glycocalyx surface. . |
| Tissue Expression | Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.,PTM:Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 7 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.,tissue specificity:Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon., |
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