CD70 Polyclonal Antibody
Ucallm_WP15954-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD70 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 150-193 |
| Specificity | The antibody detects endogenous CD70 |
| Gene Name | CD70 CD27L CD27LG TNFSF7 |
| Protein Name | CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70) |
| Other Name | CD70 antigen; / CD27 ligand; / CD27-L; / Tumor necrosis factor ligand superfamily member 7; / CD antigen CD70 |
| Species | Human |
| Gene ID | 970 |
| Uniprot | P32970, |
| Species.1 | Mouse |
| Gene ID.1 | 21948 |
| Uniprot.1 | O55237 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type II membrane protein . |
| Tissue Expression | B-cell,Kidney, |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | Function:Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer., |
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