Name: U-Blot® CD89 Rabbit mAb
SKU: WR4559
Price: 268 USD
Availability: InStock

U-Blot® CD89 Rabbit mAb

Western Blot analysis of HL-60 whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-CD89 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4559 Western Blot analysis of HL-60 whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-CD89 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4559-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Specifications

Target	CD89
Reactivity	Human
Applications	WB, IHC, IF, ICC, FC, IP
MW(Calculated)
MW(Observed)	32kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000-5000; IHC 1:100-300; ICC/IF 1:100-300; FC 1:100-300; IP 1:50-100 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT0770R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	FCAR; CD89
Protein Name	Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD antigen CD89
Other Name	FCAR; / CD89; / Immunoglobulin alpha Fc receptor; / IgA Fc receptor; / CD antigen CD89
Species	Human
Gene ID-1	2204
Uniprot	P24071
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Cellular Localization	[Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted.
Tissue Expression	Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. {ECO:0000269\|PubMed:8666819, ECO:0000269\|PubMed:8836118}.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome
Research Areas	>>Phagosome; / >>Staphylococcus aureus infection
Function	Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. {ECO:0000269\|PubMed:12768205}.
RRID