SKU: WP15598 Categories: ,

CD93 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15598-100
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Product details

Background:

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD93
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)80-100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD93. AA range:191-240
SpecificityCD93 Polyclonal Antibody detects endogenous levels of CD93 protein.
Gene NameCD93
Protein NameComplement component C1q receptor
Other NameCD93; / C1QR1; / MXRA4; / Complement component C1q receptor; / C1q/MBL/SPA receptor; / C1qR; / C1qR; / p; / C1qRp; / CDw93; / Complement component 1 q subcomponent receptor 1; / Matrix-remodeling-associated protein 4; / CD93
SpeciesHuman
Gene ID22918
UniprotQ9NPY3,
Species.1Mouse
Gene ID.1
Uniprot.1O89103
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionHighly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
Signaling_pathway
Research Areas
FunctionCaution:Has been sometimes referred to as a collectin receptor.,Caution:PubMed:11994479 reported that C1q is not a ligand for C1QR1.,Function:Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.,PTM:N- and O-glycosylated.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 5 EGF-like domains.,subunit:Interacts with HCV core protein.,tissue specificity:Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.,
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