CDA7L Polyclonal Antibody
Ucallm_WP0601-50
Price range: $268.00 through $328.00
Product details
Background:
function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1., induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line., miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation., subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction., subunit:Interacts with MYC and PSIP1., tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.,
Specifications
| Size | 50μL/100μL |
| Target | CDA7L |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 49kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Specificity | CDA7L Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CDCA7L HR1 JPO2 R1 |
| Protein Name | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) |
| Other Name | |
| Species | Human |
| Gene ID | 55536 |
| Uniprot | Q96GN5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q922M5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q4G059 |
| Cellular Localization | Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. |
| Tissue Expression | Ubiquitous. Overexpressed in medulloblastoma. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medulloblastoma., |
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