CDC25C Monoclonal Antibody
Ucallm_WM0110-50
Price range: $268.00 through $328.00
Product details
Background:
cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],
Specifications
| Size | 50μL/100μL |
| Target | Cdc25C |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA, FC |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200; FC 1:100-1:500; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 17A1 |
| Immunogen | Purified recombinant fragment of human CDC25C expressed in E. Coli. |
| Specificity | CDC25C Monoclonal Antibody detects endogenous levels of CDC25C protein. |
| Gene Name | CDC25C |
| Protein Name | M-phase inducer phosphatase 3 |
| Other Name | CDC25C; / M-phase inducer phosphatase 3; / Dual specificity phosphatase Cdc25C |
| Species | Human |
| Gene ID | 995 |
| Uniprot | P30307, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P48967 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Colon carcinoma,Epithelium,Skin,Testis, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cell cycle;Human Diseases >> Cancer: overview >> MicroRNAs in cancer |
| Research Areas | >>Cell cycle; / >>Oocyte meiosis; / >>Progesterone-mediated oocyte maturation; / >>Human immunodeficiency virus 1 infection; / >>MicroRNAs in cancer |
| Function | Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,Function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity., |
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